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Activated from the antibiotic rifampicin and different plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to unique ligands is species-certain. Activated by The natural way taking place steroids, such as pregnenolone and progesterone. Binds into a reaction component from the promoters of the CYP3A4 and ABCB1/MD